基于护理点阻抗的技术诊断动物重要传染病，加拿大国家自然基金，项目负责人，$250000加币，2022-2024（在研）

禽流感病毒快速便携式诊断设备的开发，加拿大农业基金会，项目负责人，$200000加币，2022-2024年（在研）

开发能量采集电路及其芯片上系统实现，加拿大国家自然基金，项目负责人，$100000加币，2021-2023（在研）

开发能量采集电路及其片上系统实现，加拿大阿省自然基金，项目负责人，$200000加币，2021-2023（在研）

一种用于转录谱分析的新型细胞配对微芯片，加拿大工业基金，项目负责人，$135000加币，2021-2024（在研）

用于诊断冠状病毒的自供电鼻腔可穿戴传感器，加拿大工业基金，项目负责人，$135000加币，2021-2024（在研）

开发低强度脉冲超声波电路，以提高可再生能源的纤维素生物乙醇产量，加拿大工业基金，项目负责人，$135000加币，2021-2024（在研）

基于概率的超低电源电压噪声容忍电路和系统设计，加拿大工业基金，项目负责人，$135000加币，2021-2024（在研）

用于新冠肺炎核酸检测的便携式设备，加拿大工业基金，项目负责人，$90000加币，2021-2023

使用唾液低成本快速检测COVID-19 DNA，加拿大工业基金，项目负责人，$45000 加币，2020-2021（结题）

针对严重急性呼吸系统综合征冠状病毒2型的潜在抗病毒植物分离株的提取、化学分析和配方开发，加拿大工业基金，项目负责人，$45000加币，2020-2021（结题）

设计芯片上的能量采集电路和实现系统，加拿大工业基金，项目负责人，$90000加币，2020-2022（结题）

微流控芯片实验室生物传感器的设计和微/纳米制造，加拿大国家自然基金，项目负责人，$230000加币，2021-2027（在研）

新冠肺炎快速核酸和抗体检测装置开发基础设施，加拿大国家创新基金，项目负责人，$214796加币，2020-2022（结题）

新冠肺炎快速抗体检测装置的开发和临床验证，加拿大阿省自然基金，项目负责人，$304200加币，2020-21（结题）

微流控:

1.        Book: Jie Chen, Scott MacKay, Yiwei Feng, “Bionanotechnology: Engineering Principles and Practices”, McGraw Hill, ISBN 1260464148, April 2022

2.        Songtian Bai, Pablo Gonzalez-Vasquez, Claudia Torres- Calzada, Scott MacKay, James Cook, Yeganeh Khaniani, Gareth Davies, Upasana Singh, Prashanthi Kovur, Jie Chen, David S. Wishart, “Development of a point-of-care colorimetric metabolomic sensor platform”, Biosensors and Bioelectronics, 2024 

3.        Lian C. T. Shoute, Carmen L. Charlton, Jamil N. Kanji, Shawn Babiuk, Lorne Babiuk  and Jie Chen, “Faradaic Impedimetric Immunosensor for Label-Free Point-of-Care Detection of COVID-19 Antibodies using Gold Interdigi-tated Electrode Array”, Biosensors, 2023

4.        Ahmed A. Khorshed, Oleksandra Savchenko, Jing Liu, Lian Shoute, Jie Zeng, Shifang Ren, Jianxing Gu, Naresh Jha, Zhong Yang, Jiucun Wang, Li Jin and Jie Chen, “Development of an Impedance-based Biosensor for Determination of IgG Galactosylation Levels”, Biosensors and Bioelectronics, 2023

5.        Xuanjie Ye, Tianxiang Jiang, Yuhao Ma, Daniel To, Shuren Wang, Jie Chen, “A portable, low-cost and high-throughput electrochemical impedance spectroscopy device for point-of-care biomarker detection”, Biosensors and Bioelectronics: X, 13,  pp. 100301, 2023

6.        Jeffrey T Borenstein, Gerard Cummins, Abhishek Dutta, Eyad Hamad, Michael Pycraft Hughes, Xingyu Jiang, Hyowon (Hugh) Lee, Kin Fong Lei, Xiaowu (Shirley) Tang, Yuanjin Zheng and Jie Chen, “BioNanotechnology and BioMEMS (BNM): State-ofthe-Art Applications, Opportunities, and Challenges, Lab-on-a-chip, 2023

7.        Zuyuan Tian, Zhipeng Yuan, Pedro A. Duarte, Mohamed Shaheen, Shaoxi Wang, Lacey Haddon and Jie Chen, “Highly Efficient Cell-Microbead Encapsulation Using Dielectrophoresis-Assisted Dual-Nanowell Array”, PNAS Nexus, 2023

8.        Lian C. T. Shoute, Gaser N. Abdelrasoul, Yuhao Ma, Pedro A. Duarte, Cole Edwards, Ran Zhuo, Jie Zeng, Yiwei Feng, Carmen L Charlton, Jamil N. Kanji, Shawn Babiuk, Jie Chen “Label-free Impedimetric Immunosensor for Point-of-Care Detection of COVID-19 Antibodies, Nature, Microsystems and Nanoengineering, 2022

9.        Pedro A. Duarte, Lukas Menze, Zuyuan Tian, Oleksandra Savchenko, Bingxuan Li and Jie Chen, “Dielectric analysis of Sclerotinia sclerotiorum airborne inoculum by the measurement of dielectrophoretic trapping voltages using a microfluidic platform”, Biosensors and Bioelectronics: X, 2022

10.    Yeganeh Khaniani, Mahdi Ghadiri, Yuhao Ma, Jie Zeng, David Wishart, Shawn Babiuk, Carmen Charlton, Jamil N. Kanji and Jie Chen, “A gold nanoparticle-protein G electrochemical affinity biosensor for the detection of SARS-CoV-2 antibodies – a surface modification approach”, Scientific Reports, 2022

11.    Jie Zeng, Pedro A. Duarte, Oleksandra Savchenko, Lian Shoute, Yuhao Ma, Yeganeh khaniani, Shawn Babiuk, Ran Zhuo, Gaser N. Abdelrasoul, Carmen Charlton, Jamil N. Kanji, Lorne Babiuk, Cole Edward and Jie Chen, “An impedimetric biosensor for COVID-19 serology test and modification of sensor performance via dielectrophoresis force”, Biosensors and Bioelectronics, 2022

12.    Yuhao Ma, Daniel To, Jie Zeng, Lian C. T. Shoute, Shawn Babiuk, Ran Zuo, Carmen Charlton, Jamil N Kanji, Lorne Babiuk, Jie Chen, “Improving immunoassay detection accuracy of anti-SARS-CoV-2 antibodies through dual modality validation”, Biosensors and Bioelectronics: X, 2022

13.    Lukas Menze, Pedro A. Duarte, Lacy Haddon, Michael Chu and Jie Chen, Selective Single-cell Sorting Using a Multisectorial Electroactive Nanowell Platform, ACS Nano, 16, 1, 211-220, 2022

14.    Pedro A. Duarte, Lukas Menze, Lian Shoute, Jie Zeng, Oleksandra Savchenko, Jingwei Lyu, and Jie Chen, Highly Efficient Capture and Quantification of the Airborne Fungal Pathogen Sclerotinia Sclerotiorum Employing a Nanoelectrode-activated Microwell Array, ACS OMEGA (to appear in 2022)

15.    Daniel T. Bacheschi, William Polsky, Zachary Kobos, Shari Yosinski, Lukas Menze, Jie Chen, and Mark A. Reed, “Overcoming the sensitivity – throughput tradeoff in Coulter counters: a novel side counter design”, Biosensors and Bioelectronics, 2020,

16.    Pedro A. Duarte, Lukas Menze, Gaser N. Abdelrasoul, Shari Yosinski, Zak Kobos, Riley Stuermer, Mark Reed, Jian Yang, Xiujie S. Li and Jie Chen, “Single Ascospore Detection for the Forecasting of Sclerotinia Stem Rot of Canola”, Lab on a Chip, 2020

17.    Gaser N. Abdelrasoul, Afreen Anwar, Scott Mackay, Marcus Tamura, Manzoor A. Shah, Damase P. Khasa, Ruth R. Montgomery, Albert I. Ko, Jie Chen, “DNA Aptamer-based Non-faradaic Impedance Biosensor for Detecting E. Coli”, Analytica Chimica Acta, 1107 (22), 135-144, 2020

18.    Remko van den Hurk, Masoud Baghelani, Jie Chen, Mojgan Daneshmand and Stephane Evoy, “Al-Mo Nanocomposite Functionalization for Membrane-based Resonance Detection of Bovine Herpesvirus-1”, Sensors & Actuators: A. Physical 296, 186-191, 2019

19.    Gasser N. Abdelrasoul, Scott Mackay, Saad Y. Salim, Kathleen P. Ismond, Marcus Tamura, Charfeddine Khalifa, Emma Mannan, Donghai Lin, Tanushree Mandal, Ruth R. Montgomery, David S. Wishart, Jie Chen and Rachel G. Khadaroo, “Non-Invasive Point-of-Care Device to Diagnose Acute Mesenteric Ischemia”, ACS Sensor, 3(11) 2296-2302, 2018

20.    Lian C. T. Shoute, Afreen Anwar, Scott MacKay, Gaser N. Abdelrasoul, Donghai Lin, Zhimin Yan, Anh H. Nguyen, Mark T. McDermott, Manzoor A Shah, Jian Yang, Jie Chen and Xiujie S. Li, “Immuno-impedimetric Biosensor for Onsite Monitoring of Ascospores and Forecasting of Sclerotinia Stem Rot of Canola”, Scientific Reports, 8(12396), 2018

21.    Scott MacKay, Gaser Nagah, Marcus Tamura, Donghai Lin, Zhimin Yan and Jie Chen, “Using Impedance Measurements to Characterize Surface Modified with Gold Nanoparticles”, Sensors, 17(9), 2141, 2017.

22.    Scott MacKay, Peter Hermansen, David Wishart and Jie Chen, “Simulations of interdigitated electrode interactions with gold nanoparticles for impedance-based biosensing applications”, Sensors, 15(9), 22192, 2016.

生物医疗仪器: 

1.        Ye Li, Yiqing Wu, Qi Luo, Xuanjie Ye, Jie Chen, Yuanlin Su, Ke Zhao, Xinmin Li, Jing Lin, Zhiqian Tong , Qi Wang , Dongwu Xu, “Neuropsychiatric behavioral assessments in mice after acute and long-term treatments of low-intensity pulsed ultrasound”, The American Journal of Alzheimer's Disease & Other Dementias, 2023

2.        Xuanjie Ye, Zitong Wang, Rebekah van Bruggen, Xin-Min Li, Yanbo Zhang, and Jie Chen, “Low-intensity Pulsed Ultrasound Enhances Neurite Growth in Serum-starved Human Neuroblastoma Cells”, Frontiers in Neuroscience, 2023

3.        Darian Volarić, Gordana Žauhar, Jie Chen, Ana Terezija Jerbić Radetić, Olga Cvijanović Peloza, “Stimulation of critical size bone defect repair after application of low-intensity pulsed ultrasound”, excellent poster award in Ultrasonics 2023. ·        Xuanjie Ye,Tianxiang Jiang,Yuhao Ma,Daniel To,Shuren Wang and Jie Chen, “A Portable, Low-cost and High-throughput Electrochemical Impedance Spectroscopy Device for Point-of-care Biomarker Detection, Biosensors and Bioelectronics: X, 2023

4.        Zhongyuan Fang, Fei Gao, Haoran Jin, Siyu Liu, Wensong Wang, Ruochong Zhang, Zesheng Zheng, Xuan Xiao, Kai Tang, Liheng Lou, Kea-Tiong Tang, Jie Chen and Yuanjin Zheng, “A Review of Emerging Electromagnetic-Acoustic Sensing Techniques for Healthcare Monitoring, IEEE Transaction on Biomedical Circuits and Systems, 2022

5.        Xuanjie Ye, Lexi Wu, Kaining Mao, Yiwei Feng, Jiajun Li, Lei Ning, and Jie Chen, “Bioimpedance Measurement of Knee Injuries using Bipolar Electrode Configuration”, IEEE Transaction on Biomedical Circuits and Systems, 2022

6.        Huining Guo, Glen Baker, Kelly Hartle, Ester Fujiwara, Junhui Wang, Yanbo Zhang, Jida Xing, Haiyan Lyu, Xin-Min Li, and Jie Chen, Exploratory Study on Neurochemical Effects of Low Intensity Pulsed Ultrasound in Brains of Mice, Medical & Biological Engineering & Computing, 2021

7.        Oleksandra Savchenko, Jida Xing, Mark Burrell, Robert Burrell and Jie Chen, “Impact of Low-intensity Pulsed Ultrasound on the Growth of Schizochytrium sp. for Omega-3 Production”, Biotechnology and Bioengineering, 2020

8.        Xiaoxue Jiang, Wai Tung Ng and Jie Chen, “A Miniaturized Low-Intensity Ultrasound Device for Wearable Medical Therapeutic Applications”, IEEE Transaction on Biomedical Circuits and Systems, special issue on Wearable and Flexible Integrated Sensors for Screening, Diagnostics, and Treatment, 13(16) 1372-1382, 2019

9.        Xiaoxue Jiang, Oleksandra Savchenko, Yufeng Li, Shiang Qi, Tianlin Yang, Wei Zhang and Jie Chen, “A Review of Low-intensity Pulsed Ultrasound for Therapeutic Applications”, Transactions on Biomedical Engineering, 66(10) 2704-2718, 2019

10.    Jida Xing, Shrishti Singh, Yupeng Zhao, Yan Duan, Huining Guo, Chenxia Hu, Allan Ma, Rajan George, James Z. Xing, Ankarao Kalluri, Isaac G. Macwan, Prabir Patra, and Jie Chen, “Increasing Vaccine Production Using Pulsed Ultrasound Waves”, PLOS ONE, 12(11), 2017

11.    Michael C. Schultz, Jian Zhang, Xian Luo, Oleksandra Savchenko, Liang Li, Michael Deyholos and Jie Chen, “Impact of Low-Intensity Pulsed Ultrasound on Transcript and Metabolite Abundance in Saccharomyces cerevisiae”, Journal of Proteome Research, 16(8), 2975-2982, 2017

12.    Oleksandra Savchenko, Jida Xing, Xiaoyan Yang, Quanrong Gu, Mohamed Shaheen, Min Huang, Xiaojian Yu, Robert Burrell, Prabir Patra and Jie Chen, “Algal Cell Response to Pulsed Waved Stimulation and Its Application to Increase Algal Lipid Production”, Scientific Reports, 7(42003), 2017

13.    Yupeng Zhao, Jida Xing, James Z. Xing, Woon T. Ang, and Jie Chen, “Applications of Low-intensity Pulsed Ultrasound to Increase Monoclonal Antibody Production in CHO Cells Using Shake Flasks or Wavebags,” Ultrasonics, Vol. 54, No. 6, 2014, 1439–1447. Invited to speak at the Cambridge Healthtech Institute’s Annual Recombinant Protein Expression and Production meeting, Jan. 2015 in San Diego, USA.

14.    Mohamed Shaheen, Michael Choi, Woon Ang, Yupeng Zhao, James Xing, Ray Yang, Jida Xing, Jian Zhang and Jie Chen, “Application of Low-Intensity Pulsed Ultrasound to Increase Bio-ethanol Production,” Renewable Energy Volume 57, 2013, 462-468

15.    Peng Xu, Hilal Gul-Uludag, Woon T. Ang, Xiaoyan Yang, Min Huang, Leah Marquez-Curtis, Locksley McGann, Anna Janowska-Wieczorek, James Xing, Eric Swanson and Jie Chen, “Low-intensity pulsed ultrasound-mediated stimulation of hematopoietic stem/progenitor cell viability, proliferation and differentiation in vitro,” Biotechnology Letters, 2012, 34(10):1965-1973

16.    Yupeng Zhao, Woon T. Ang, James Xing, Jian Zhang, and Jie Chen, “Applications of Ultrasound to Enhance Mycophenolic Acid Production,” Ultrasound in Med. & Biol., 2012, 38(9):1582–1588

17.    James Z Xing, Xiaoyan Yang, Peng Xu, Woon T. Ang, and Jie Chen, “Ultrasound Enhanced Monoclonal Antibody Production,” Ultrasound in Medicine and Biology, 2012, 38(11):1949–1957

18.    W. T. Ang, Cristian Scurtescu, Wing Hoy, Tarek El-Bialy, Ying Tsui and Jie Chen, “Design and Implementation of Therapeutic Ultrasound Generating Circuit for Dental Tissue Formation and Tooth-Root Healing,” IEEE Trans. on Biomedical Circuits and Systems, 2010, 4(1)

集成电路

1.        Shuren Wang, Xiaoxue Jiang, Heng Pan, Xuanjie Ye, Jie Chen, An Integrated RF Energy Harvesting System with Broad Input Voltage Range and High Power Conversion Efficiency, The Proceedings of the National Academy of Sciences (PNAS), 2023.

2.        Yufeng Li, Yan Li, Deqiang Cheng, Fan Yang, Xuan Zeng and Jie Chen, “Improved Low-Power Cost-Effective DCT Implementation Based on Markov Random Field and Stochastic Logic”, IEEE Trans. on Video technology, 30(10), 2019Yufeng Li, Yan Li, Deqiang Cheng, Fan Yang, Xuan Zeng and Jie Chen, “Improved Low-Power Cost-Effective DCT Implementation Based on Markov Random Field and Stochastic Logic”, IEEE Trans. on Video technology, 30(10), 2019

3.        Yan Li, Yufeng Li, Han Jie, Jianhao Hu, Fan Yang, Xuan Zeng, Bruce Cockburn and Jie Chen, “Feedback-based Low-Power Soft-Error Tolerant Design for Dual Modular Redundancy”, IEEE Transactions on Very Large Scale Integrated Systems, 26(8), 2018

4.        Yan Li, Yufeng Li, I-Chyn Wey, Fan Yang, Xuan Zeng, Xiaoxue Jiang and Jie Chen, Low-Power Noise-Immune Nanoscale Circuit Design Using Coding-based Partial MRF Method, IEEE Journal of Solid State Circuits, 53(8), 2018

5.        I-Chyn Wey, You-Gang Chen, Changhong Yu, An-Yeu (Andy) Wu and Jie Chen, “Design and implementation of cost-effective probabilistic-based noise-tolerant VLSI circuits,” IEEE Transactions on Circuits and Systems – I: Regular Papers, 2009, 56(11)

6.        Iris R. Bahar, Jie Chen and Joe Mundy “A Probabilistic-based Design Methodology for Nanoscale Computation,” IEEE/ACM International conference on computer-aided circuit design, San Jose, USA, November 2003

人工智能

1.        Wei Zhang, Kaining Mao, and Jie Chen, “A Multimodal Approach for Detection and Assessment of Depression Using Text, Audio and Video”, Phenomics, 2023

2.        Kaining Mao, Yuqi Wu, Jie Chen, A Systematic Review on Automated Clinical Depression Diagnosis, Nature npj Mental Health, 2023

3.        Yuqi Wu, Kaining Mao, Liz Dennett, Yanbo Zhang, Jie Chen, A Systematic Review of Machine Learning in PTSD Studies: Evaluating AI-based Automated PTSD Diagnosis, Nature npj Mental Health, 2023

4.        Kaining Mao, Deborah B. Wang, Tiansheng Zheng, Rongqi Jiao, Yanhui Zhu, Bin Wu, Lei Qian, Wei Lyu, Jie Chen and Minjie Ye, “Analysis for Automated Clinical Depression Diagnosis in a Chinese Corpus”, IEEE Transactions on Circuits and Systems, 2023

5.        Kaining Mao, Wei Zhang, Deborah Baofeng Wang, Ang Li, Rongqi Jiao, Yanhui Zhu, Bin Wu, Tiansheng Zheng, Lei Qian, Wei Lyu, Minjie Ye, and Jie Chen, “Prediction of Depression Severity Based on the Prosodic and Semantic Features with Bidirectional LSTM and Time Distributed CNN”, IEEE Transaction on Affective Computing, Feb. 2022

6.        Dan Jin, Philippe Henry, Jacqueline Shan, Jie Chen, “Identification of chemotypic markers in three chemotype categories of cannabis using secondary metabolites profiled in inflorescences, leaves, stem bark, and roots”, Frontiers, 7, 2021

7.        Dan Jin, Philippe Henry, Jacqueline Shan, Jie Chen, “Classification of cannabis strains in the Canadian market with discriminant analysis of principle components using genome-wide single nucleotide polymorphisms”, PLOS One, 6, 2021

8.        Shi-ang Qi, Qian Wu, Zhenpu Chen, Wei Zhang, Yongchun Zhou, Kaining Mao, Jia Li, Yuanyuan Li, Jie Chen, Youguang Huang, Yunchao Huang, “High-resolution Metabolomic Biomarkers for Lung Cancer Diagnosis and Prognosis”, Scientific Reports 11 (11805), 2021

9.        Dan Jin, Philippe Henry, Jacqueline Shan, Jie Chen, “Identification of Phenotypic Characteristics in Three Chemotype Categories in the Genus Cannabis”, HortScience, 56(4), 2020

10.    Dan Jin, Kaiping Dai, Zhen Xie, Jie Chen, “Secondary Metabolites Profiled in Cannabis Inflorescences, Leaves, Stem Barks, and Roots for Medicinal Purposes. Scientific Reports. 10(1):1-14, 2020

生物材料

1.        Meng Xiao, Jinlin Wu, Duanduan Chen, Chenghu Wang, Yanfen Wu, Tucheng Sun and Jie Chen, “Ascending Aortic Volume: A Feasible Indicator for Ascending Aortic Aneurysm Elective Surgery?”, Acta Biomaterialia (impact factor 10.63), 2023

2.        Wei Zhang, Gaser N. Abdelrasoul, Oleksandra Savchenko, Abdalla Abdrabou, Zhixiang Wang, Jie Chen, “Ultrasound-assisted Magnetic Nanoparticle-based Gene Delivery”, PLOS One, 2020

3.        Anh H. Nguyen, Gaser N. Abdelrasoul, Donghai Lin, Hamid Maadi, Junfeng Tong, Grace Chen, Richard Wang, Afreen Anwar, Lian Shoute, Qiang Fang, Zhixiang Wang and Jie Chen, “Polyethylenimine-coated Iron Oxide Magnetic Nanoparticles for High Efficient Gene Delivery”, Applied Nanoscience, 8(4) 811-821, 2018

4.        Wuyang Jin, Donghai Lin, Anh H. Nguyen, Gaser N. Abdelrasoul, Jian Chen, Arthur Mar, Qiang Fang, Yutian Wang and Jie Chen, “Transfection of Difficult-to-transfect Rat Primary Cortical Neurons with Magnetic Nanoparticles”, Journal of Biomedical Nanotechnology, 14(9) 1654-1664, 2018

5.        Weiting Gu, Jie Chen, Prabir Patra, Xiaoyan Yang, Quanrong Gu, Lingxuan Wei, Jason P. Acker, and Beihua Kong, “Nanoformulated Water-Soluble Paclitaxel to Enhance Drug Efficacy and Reduce Hemolysis Side Effect”, Journal of Biomaterials Applications, 32(1):66-73, 2017

6.        Martin Niestroj, Jie Chen, Dean Chapman, Darrell Mousseau, Brian Bewer, Nicholas Bolibruch, and Josef Hormes, “Experimental-focused radio-sensitizing studies of gold nanoparticles in the low-to-middle X-ray regime,” Biology and Synchrotron Radiation (BSR) - Hamburg/Germany September 2013. Received the best poster award by the International Union of Crystallography. Martin Niestro, Brian Bewer, Darrell Mousseau, Dean Chapman, Jie Chen and Joseph Hormes, “A Monochromatic X-ray Irradiation System for In Vitro Studies at Synchrotron Beamlines”, Biomedical Physics & Engineering Express, 2(5), 2016

7.        Wilson Roa, Xiaojing Zhang, Linghong Guo, Andrew Shaw, Xiuying Hu, Yeping Xiong, Sunil Gulavita, Samir Patel, Xuejun Sun, Jie Chen, Ronald Moore, and James Z. Xing, “Gold-nanoparticles sensitize radiotherapy of prostate cancer cells by regulation of cell cycle,” Nanotechnology, 2009, 20:375101

8.        W. Zhu, Q.W. Shi, X.R. Wang, Jie Chen, Jinlong Yang, Jianguo Hou, “Shape of disorder broadened Landau subbands in grapheme,” Physical Review Letters, 2009, 102:056803

9.        Tao Kong, Jie Zeng, Xiaoping Wang, Xiaoyan Yang, Jing Yang, Steve McQuarrie, Alexander McEwan, Wilson Roa, Jie Chen and James Z. Xing, “Enhancement of radiation cytotoxicity in breast cancer cells by localized attachment of gold nanoparticles”, Wiley-VCH SMALL Journal, 2008, 9:1537-1543